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Effect of NRSE removal on L1 gene expression
| Stage | Tissue | Effect on expression | Silencer or enhancer |
|---|---|---|---|
| P1 | Entire brain | ↑ | S |
| P1 | Cerebellum: molecular layer | ↑ | S |
| P1 | Ear: spiral ganglion | ↑ | S |
| P1 | Eye: amacrine, photoreceptor layers | ↓ | E |
| P5 | Cerebellum: internal granule layer | ↓ | E |
| Adult | Cortex, striatum, hippocampus | ↓ | E |
| P1, P5 | Olfactory nerve layer in bulb | ↑ | S |
| Adult | Thalamus | ↑ | S |
| All stages | Nonneural tissues | ↑ | S |
S, silencer; E, enhancer.
