Figure 5.

Fluoxetine- or fluvoxamine-elicited increase in the ALLO content of CSF correlates with the improvement in the HAM-D score [r = 0.58; P < 0.023; Pearson’s Product Moment Correlation (18)]. The percent changes in HAM-D scores before and after fluoxetine and fluvoxamine treatment (abscissa) were plotted against changes in corresponding ALLO levels in the CSF (ordinate). For each patient the change in ALLO levels in the CSF before and after treatment reflects the mean of the difference between ALLO level before and after SSRI treatment in the four cisternal–lumbar CSF fractions.