Table 1.
Content of ALLO and two of its precursors in CSF of depressed patients before and after treatment with fluoxetine or fluvoxamine
| Patient | Sex | Age, years | Drug
|
PREG, fmol/ml
|
PROG, fmol/ml
|
ALLO, fmol/ml
|
HAM-D | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Name | mg per kg per day | Before | After | Before | After | Before | After | ||||
| 1 | F | 31 | FX | 0.18 | 94 ± 17 | 110 ± 17 | — | — | 7.0 ± 0.72 | 24 ± 2.2* | 30/1 |
| 2 | F | 29 | FX | 0.68 | 120 ± 21 | 120 ± 14 | 250 ± 11 | 300 ± 10 | 21 ± 3.6 | 32 ± 2.0* | 23/0 |
| 3 | F | 30 | FX | 0.65 | 69 ± 6.9 | 66 ± 7.9 | 570 ± 31 | 350 ± 50 | 13 ± 1.6 | 46 ± 1.4* | 23/1 |
| 4 | M | 46 | FX | 0.34 | — | — | 19 ± 3.8 | 17 ± 4.1 | 12 ± 0.75 | 20 ± 1.0* | 28/4 |
| 5 | F | 41 | FX | 1.5 | 50 ± 3.1 | 41 ± 4.7 | 150 ± 16 | 180 ± 22 | 11 ± 2.1 | 40 ± 1.5* | 25/10 |
| 6 | F | 41 | FX | 0.6 | 60 ± 12 | 53 ± 7.2 | 15 ± 2.8 | 18 ± 3.5 | 30 ± 2.0 | 44 ± 6.8* | 24/14 |
| 7 | M | 37 | FX | 0.27 | 50 ± 4.1 | 41 ± 6.6 | 17 ± 2.5 | 22 ± 5.0 | 12 ± 1.9 | 13 ± 1.9 | 24/23 |
| 8 | M | 51 | FV | 0.54 | 50 ± 4.4 | 70 ± 14 | 29 ± 1.4 | 23 ± 2.1 | 7.2 ± 0.42 | 29 ± 2.5* | 22/3 |
| 9 | F | 23 | FV | 0.95 | 85 ± 25 | 100 ± 4.7 | 44 ± 6.6 | 47 ± 7.2 | 15 ± 1.5 | 72 ± 3.8* | 26/1 |
| 10 | F | 45 | FV | 0.58 | 94 ± 23 | 110 ± 11 | 600 ± 60 | 790 ± 90 | 13 ± 2.6 | 26 ± 4.6* | 23/0 |
| 11 | M | 48 | FV | 0.66 | 85 ± 16 | 66 ± 14 | 66 ± 5.0 | 180 ± 11* | 19 ± 2.8 | 12 ± 0.87 | 30/25† |
| 12 | M | 48 | FV | 0.63 | 38 ± 3.1 | 35 ± 4.4 | 25 ± 6.9 | 19 ± 4.1 | 14 ± 1.6 | 9.2 ± 0.97 | 25/26† |
| 13 | F | 35 | FV | 2.88 | 57 ± 9.8 | 50 ± 13 | 290 ± 31 | 440 ± 27* | 20 ± 1.9 | 54 ± 5.2* | 26/15 |
| 14 | F | 40 | FV | 1.61 | 44 ± 8.5 | 66 ± 25 | 170 ± 31 | 190 ± 41 | 14 ± 1.5 | 30 ± 2.0* | 27/16 |
| 15 | M | 48 | FV | 0.87 | 41 ± 6.9 | 38 ± 5.0 | 23 ± 2.2 | 17 ± 2.5 | 17 ± 1.6 | 19 ± 1.1 | 28/22 |
Steroids were measured in four different cisternal–lumbar CSF fractions in the same patient. Because there was not a significant cisternal–lumbar gradient for ALLO (3α5α-ALLO + 3α5β-ALLO; see Fig. 2), PREG, and PROG, each of the four values obtained by the analysis of the gradient fractions was considered a replication of the same sample. Therefore, for each steroid, we computed the mean ± SEM of four samples for each subject in this table. For each patient, differences before and after treatment were evaluated with an unpaired t test (P < 0.01). FX, fluoxetine; FV, fluvoxamine; F, female; M, male.
Significantly different values before and after treatment.
In these patients, HAM-D scores were obtained seven days before collection of CSF. In all the other patients, the HAM-D scores were obtained a few hours before spinal tap.