Table 1.

Effects of Pasipay on PTZ-induced convulsion in mice

Treatment (dose)	Onset (sec)	Duration (sec)	Seizure protection (%)	Mortality protection (%)
Normal saline (10 ml/kg)	51.83 ± 64	12 ± 1.80	0	0
Diazepam (0.5 mg/kg)	485.5 ± 74.97***	3.5 ± 2.21*	80	90
Diazepam (1 mg/kg)	600 ± 0***	0 ± 0***	100	100
Pasipay (0.05 mg/kg)	56 ± 4.51	15.3 ± 4.48	0	0
Pasipay (0.1 mg/kg)	112.66 ± 16.2	7.1 ± 2.5	10	50
Pasipay (0.2 mg/kg)	137.6 ± 17.8***	7 ± 1.1	20	80
Pasipay (0.4 mg/kg)	600 ± 0***	0 ± 0***	100	100

Normal saline, diazepam and Pasipay were administered i.p. 30 min before the injection of PTZ (90 mg/kg, i.p.); Values are the mean ± S.E.M. for 10 mice. *p < 0.05;*** p < 0.001, compared to saline group, Tukey-Kramer test.