Table 2.
Treatment (dose) | Onset (sec) | Duration (sec) | Mortality protection (%) |
Normal saline (10 ml/kg) | 51.83 ± 64 | 12 ± 1.80 | 0 |
Flumazenil (2 mg/kg) | 44.71 ± 1.44 | 8.25 | 85 |
Diazepam (0.5 mg/kg) | 485.5 ± 74.97*** | 3.5 ± 2.21* | 90 |
Diazepam+ Flumazenil | 152.5 ± 28.9 | 12.25 ± 3.42 | 70 |
Pasipay (0.4 mg/kg) | 600 ± 0*** | 0 ± 0*** | 100 |
Pasipay+ Flumazenil | 184.33 ± 29.1 | 11 ± 1.52 | 50 |
Normal saline, diazepam and Pasipay were administered (i.p.) 30 min before the PTZ (90 mg/kg, i.p.); Flumazenil was administered 35 min before the injection of PTZ (90 mg/kg, i.p.); Values are the mean ± S.E.M. for 10 mice; *p < 0.05; ***p < 0.001, compared with saline group, Tukey-Kramer test.