Secretion of cytokines in responses to VLP stimulation. Bars indicate standard deviations from six mice per group. A) IFN-γ, B) TNF-α, C) IL-4, D) IL-10. Naïve: unimmunized mice, WT: immunized mice with wild type SHIV VLPs, dV1V2: immunized mice with dV1V2 SHIV VLPs, 3G: immunized with 3G SHIV VLPs, 3G-dV2−1G: immunized mice with 3G-dV2−1G SHIV VLPs.