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. 1998 Mar 17;95(6):3287–3294. doi: 10.1073/pnas.95.6.3287

Table 1.

Parameters of nonlinear fittings of I-V curves and isochronic (2 s) inactivation curves

α1C subunit I-V curve*
Isochronic inactivation curve†
V0.5 (mV)
V0.5 (mV)
IBa ICa n(IBa/ICa) IBa ICa n(IBa/ICa)
77 4.45  ±  0.77 10.30  ±  0.90 13/15 −6.14  ±  0.86 −15.17  ±  1.66 10/6
77d80 18.64  ±  1.08 25.46  ±  1.42 10/4 −17.30  ±  1.28 −20.44  ±  2.02 8/4
77d42 20.41  ±  0.42 27.25  ±  1.23 5/3 −5.21  ±  0.69 −10.22  ±  1.31 5/3
77d31 10.83  ±  3.05 19.26  ±  3.03 6/3 −22.64  ±  1.12 −25.67  ±  2.23 6/3
77d21 8.64  ±  2.51 16.40  ±  2.84 5/3 −18.14  ±  0.68 −22.45  ±  1.01 4/3
77d12 18.95  ±  1.15 17.03 7/1 −8.23  ±  1.20 −16.95 7/1
77d68 18.22  ±  2.32 19.84  ±  2.22 6/6 −16.54  ±  1.68 −23.21  ±  2.49 6/5
77d38 17.73  ±  1.53 22.02  ±  1.44 7/5 −10.82  ±  1.30 −16.03  ±  1.59 6/5
77d48 20.15  ±  2.51 21.23  ±  1.44 5/4 −13.54  ±  2.39 −21.39  ±  2.45 5/4
77d18 19.42  ±  2.36 22.71  ±  1.95 6/4 −9.81  ±  1.93 −14.98  ±  1.53 5/4
77d08 13.57  ±  1.34 18.02  ±  1.92 10/6 −14.96  ±  1.65 −16.36  ±  2.33 5/5
77d20 −0.72  ±  0.87 6.00  ±  1.94 7/5 −17.07  ±  1.22 −27.52  ±  2.22 8/4
77d30 3.41  ±  2.52 9.92  ±  1.66 5/7 −14.55  ±  1.33 −21.64  ±  2.85 6/4
77d10 4.69  ±  2.19 13.16  ±  2.12 9/5 −20.24  ±  1.28 −23.93  ±  2.68 5/3
77d50 10.34  ±  3.38 18.83  ±  1.01 4/3 −15.57  ±  0.07 −22.58  ±  1.13 3/3
77dEF 13.35  ±  1.75 21.60  ±  1.55 6/3 −10.31  ±  3.43 −13.61  ±  2.00 4/3
*

TPs in the range of −40 to +80 mV were applied in 10 mV increments from Vh = −90 mV. I-V curves were fitted by I = Gmax(V − Erev)/{1 + exp[(V − V0.5)/k]}, where Gmax = maximum conductance; Erev = reversal potential; V0.5 = voltage at 50% of Gmax; k = negative slope factor. 

†

From Vh = −90 mV 2-s conditioning PP were applied in 10 mV increments from −60 up to +20 mV, each followed by a 1-s TP to +20 mV. The interval between TPs was 30 s. Recorded peak current amplitudes were normalized to IBa at −60 mV. Isochronic inactivation curves were fitted by a Boltzmann function: I = 1/{1 + exp[(V − V0.5)/k]}, where V is the conditioning PP voltage, V0.5 is the voltage at half-maximal inactivation, and k is a slope factor. Values are means ± SEM. n = number of tested oocytes.