Table 3.
Tick bite infection of mice with B. burgdorferi clones lacking or containing lp36.
| Mouse infection by larval tick bitea | Mouse infection by nymphal tick bitea | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reisolation from tissuesc | Reisolation from tissuesc | |||||||||||
| Clone | Serologyb | Ear | Bladder | Joint | No. mice infected/total | P-valued | Serologyb | Ear | Bladder | Joint | No. mice infected/total | P-valued |
| A3-M9 lp36-minus | 2/5 | 2/5 | 0/5 | 0/5 | 2/5 | 0.52 | 2/5 | 2/5 | 1/5 | 0/5 | 2/5 | 0.17 |
| A3-M9 lp36-minus/lp36-gent | 4/5 | 4/5 | 4/5 | 4/5 | 4/5 | 4/4e | 4/4 | 4/4 | 4/4 | 4/4 | ||
a
Number of mice infected/number of mice analysed. Pooled data from three separate tick feeding experiments unless otherwise noted.
b
Assessed by immunoblot analysis with cell lysates of B. burgdorferi and E. coli producing P39 recombinant protein at 3, 5 and 7 weeks post inoculation.
c
Mice were sacrificed and tissues harvested 7 weeks post inoculation.
d
The P-value was calculated by Fischer's exact test for the number of infected mice in the two groups.
e
Pooled data from two separate tick feeding experiments.