Table 1.
Clinical and baseline characteristics of the population studied
| Background metformin | Background sulphonylurea | |||
|---|---|---|---|---|
| Rosiglitazone | Sulphonylurea | Rosiglitazone | Metformin | |
| Patients (n) | 259 | 265 | 311 | 284 |
| Age (years) | 57 ± 8 | 57 ± 8 | 61 ± 8 | 60 ± 8 |
| Male [n (%)] | 141 (54) | 139 (52) | 152 (49) | 149 (52) |
| Europid [n (%)] | 257 (99) | 263 (99) | 309 (99) | 281 (99) |
| Time from diagnosis (years) | 6.1 ± 4.3 | 7.0 ± 5.6 | 7.9 ± 5.7 | 8.1 ± 5.4 |
| Body weight (kg) | 93 ± 17 | 91 ± 15 | 84 ± 14 | 83 ± 12 |
| Body mass index (kg/m2) | 32.7 ± 5.4 | 32.3 ± 4.8 | 30.1 ± 3.8 | 29.8 ± 3.9 |
| HbA1c (%) | 7.9 ± 0.70 | 7.8 ± 0.66 | 8.0 ± 0.69 | 8.0 ± 0.77 |
| Fasting plasma glucose (mmol/l) | 9.7 ± 2.38 | 9.7 ± 2.23 | 10.2 ± 2.54 | 10.1 ± 2.24 |
| Homeostasis model assessment %B (%) | 30.6 (19.5, 44.2) | 30.9 (17.6, 47.3) | 24.3 (15.9, 37.9) | 22.2 (14.2, 36.8) |
| Homeostasis model assessment %S (%) | 29 (19, 43) | 30 (17, 45) | 29 (20, 45) | 32 (21, 49) |
| C-reactive protein (mg/l) | 3.6 (1.7, 7.2) | 3.0 (1.4, 7.1) | 2.5 (1.3, 4.6) | 2.9 (1.2, 5.2) |
| Plasminogen activator inhibitor-1 antigen (µg/l) | 60 (39, 84) | 55 (38, 87) | 60 (40, 91) | 62 (40, 92) |
| Fibrinogen (g/l) | 3.2 (2.8, 3.7) | 3.2 (2.7, 3.6) | 3.2 (2.8, 3.7) | 3.3 (2.9, 3.8) |
| Insulin (pmol/l) | 61 (41, 89) | 57 (39, 97) | 57 (36, 80) | 53 (34, 71) |
| Proinsulin (pmol/l) | 9.1 (5.8, 16.0) | 9.6 (6.3, 15.7) | 11.8 (7.7, 19.6) | 10.9 (7.0, 17.5) |
| Proinsulin:insulin ratio (pmol/pmol) | 0.16 (0.10, 0.25) | 0.16 (0.10, 0.25) | 0.23 (0.14, 0.36) | 0.23 (0.15, 0.36) |
| Total cholesterol (mmol/l) | 5.4 ± 0.92 | 5.4 ± 1.02 | 5.6 ± 1.04 | 5.6 ± 1.09 |
| Triglycerides (mmol/l) | 2.2 ± 1.11 | 2.1 ± 1.32 | 2.1 ± 1.88 | 2.1 ± 1.45 |
| High-density lipoprotein cholesterol (mmol/l) | 1.2 ± 0.27 | 1.2 ± 0.28 | 1.2 ± 0.31 | 1.2 ± 0.32 |
| Low-density lipoprotein cholesterol (mmol/l) | 3.2 ± 0.79 | 3.2 ± 0.84 | 3.5 ± 0.87 | 3.5 ± 0.96 |
| Non-esterified fatty acids (mmol/l) | 0.63 ± 0.22 | 0.63 ± 0.24 | 0.66 ± 0.25 | 0.64 ± 0.24 |
Number (%), mean ± sd, or median (IQR).