Table 3.
Comparison of the results observed in our cohort and in the main studies in the literature
| Study | Year | Duration of study (months) | No. of patients | % GH control | % IGF-1 control | % GH and IGF-1 control | DEF shrinkage/ % shrinkage (n) | Mean decreased volume | Diarrhoea | Lithiasis |
|---|---|---|---|---|---|---|---|---|---|---|
| Lundin et al.16 | 1997 | 34 | 18 | NA | NA | NA | ⇑ Vol > 18/72 (11) | 51 (26–67) | NA | NA |
| Baldelli et al.17 | 2000 | 24 | 118 | 77 | 63 | NA | ⇑ Vol > 20/22 (23) | NA | 46 | 12 |
| Colao et al.18 | 2001 | 24 | 36 | 71 | 68 | NA | ⇑ Vol > 25/80 (15) | 53 (18–100) | 28 | 8 |
| Ayuk et al.19 | 2002 | 41 | 22 | 36 | 67 | NA | NA | NA | NA | 23 |
| Bevan et al.20 | 2002 | 6 | 27 | 79 | 53 | 50 | ⇑ Vol > 10/96 (27) | 49 (12–73) | NA | 26 |
| Amato et al.21 | 2002 | 24 | 20 | 35 | 45 | NA | ⇑ Vol > 10/95 (20) | 28 | NA | NA |
| Cozzi et al.22 | 2003 | 30 | 110 | 63 | 65 | NA | ⇑ Vol > 25/91 (11) | NA | 9 | 18 |
| Cozzi et al.23 | 2006 | 48 | 67 | 68·7 | 70·1 | 56·7 | ⇑ Vol > 25/82 | 62 | NA | 12 |
| This work | 2006 | 96 | 36 | 70 | 67 | 58 | ⇑ Vol > 20/72 | 43 | 30 | 36 |
NA, not available. The shrinkage was studied in the event of primary treatment (this is why the number of patients is lower than the total number in the various studies).