Table 3.

GH and IGF-1 response rates after 24 and 48 weeks of treatment

Week/Outcome		Total N = 68% (n) [95% CI]	Microadenomas N = 8% (n) [95% CI]*	Macroadenomas N = 60% (n) [95% CI]
Week 24
Any GH response		72·1 (49) [60·6, 83·5]	100·0 (8) [63·1, 100·0]	68·3 (41) [55·6, 81·0]
	Complete GH response(mGH ≤ 2·5 µg/l)	42·6 (29) [30·1, 55·2]	87·5 (7) [47·4, 99·7]	36·7 (22) [23·5, 49·8]
	Partial response GH(mGH > 2·5 and ≤ 5 µg/l)	29·4 (20) [17·8, 41·1]	12·5 (1) [0·0, 52·7]	31·7 (19) [19·0, 44·4]
Any IGF-1 response		55·9 (38) [43·3, 68·5]	100·0 (8) [63·1, 100·0]	50·0 (30) [36·4, 63·6]
	Complete IGF-1 response(normal for age and sex)	38·2 (26) [25·9, 50·6]	75·0 (6) [34·9, 96·8]	33·3 (20) [20·5, 46·2]
	Partial IGF-1 response(≥ 50% reduction)	17·6 (12) [7·8, 27·5]	25·0 (2) [3·2, 65·1]	16·7 (10) [6·3, 27·0]
Week 48
Any GH response		67·6 (46) [55·7, 79·6]	100·0 (8) [63·1, 100·0]	63·3 (38) [50·2, 76·5]
	Complete GH response(mGH ≤ 2·5 µg/l)	44·1 (30) [31·5, 56·7]	75·0 (6) [34·9, 96·8]	40·0 (24) [26·7, 53·3]
	Partial GH response(mGH > 2·5 and ≤ 5 µg/l)	23·5 (16) [12·6, 34·4]	25·0 (2) [3·2, 65·1]	23·3 (14) [11·7, 35·0]
Any IGF-1 response		48·5 (33) [35·8, 61·2]	75·0 (6) [34·9, 96·8]	45·0 (27) [31·5, 58·5]
	Complete IGF-1 response(normal for age and sex)	33·8 (23) [21·8, 45·9]	50·0 (4) [15·7, 84·3]	31·7 (19) [19·0, 44·4]
	Partial IGF-1 response(≥ 50% reduction)	14·7 (10) [5·5, 23·9]	25·0 (2) [3·2, 65·1]	13·3 (8) [3·8, 22·8]

^*Using exact calculation method because of the small number of subjects.