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. Author manuscript; available in PMC: 2007 Oct 1.

Published in final edited form as: Neuroscience. 2006 Jun 2;141(2):607–620. doi: 10.1016/j.neuroscience.2006.04.043

Fig. 8 — Hypothetical model of β-BG-Dp116, -Up395 and -Up71 interaction in C57BL/10 and mdx peripheral nerve. a) β-BG is localized in the Schwann cell outer membrane, whereas Dp116 and Up395 are localized in the Schwann cell cytoplasm. b) Normal (C57BL/10) and mdx Schwann cell membrane. The processing of β-BG_full to β-BG₃₀ by MMPs (MMP-2 and MMP-9) leads to the disruption of the link between the basal lamina and the outer membrane. The Up71 anchorage to β-BG₃₀ could stabilize this isoform in Schwann cell membrane to avoid any dysfunction in mdx nerve physiology.

Fig. 8 — Hypothetical model of β-BG-Dp116, -Up395 and -Up71 interaction in C57BL/10 and mdx peripheral nerve. a) β-BG is localized in the Schwann cell outer membrane, whereas Dp116 and Up395 are localized in the Schwann cell cytoplasm. b) Normal (C57BL/10) and mdx Schwann cell membrane. The processing of β-BG_full to β-BG₃₀ by MMPs (MMP-2 and MMP-9) leads to the disruption of the link between the basal lamina and the outer membrane. The Up71 anchorage to β-BG₃₀ could stabilize this isoform in Schwann cell membrane to avoid any dysfunction in mdx nerve physiology.