Table I.

For the basic model and several models with one, two or three covariates on log(CL/F): Log-likelihood (LL), BIC and estimated fixed effects (β) of the covariates with the corresponding p-value of the Wald test

Model	Cov 1	Cov 2	Cov 3	LL	BIC	β1	pval1	β2	pval2	β3	pval3
1				−1241.48	2482.96
2	Sex			−1240.85	2487.18	0.416	0.2651
3	Age			−1240.82	2487.12	−0.013	0.4475
4*	BMI			−1236.83	2479.14	0.107	0.0024
5	CLCR			−1239.61	2484.70	0.013	0.0211
6*	Diarrhea			−1237.00	2479.48	−0.982	0.0027
7	CD4			−1238.40	2482.28	0.002	0.0144
8	Xylose			−1239.95	2485.38	0.599	0.0367
9	L/M			−1240.05	2485.58	−4.677	0.0326
10	St. weight			−1240.61	2486.70	−0.001	0.2333
11	APL			−1239.98	2485.44	−0.001	0.1606
12	Albumine			−1240.13	2485.74	0.029	0.1590
13	CLCR	BMI		−1236.13	2483.22	0.007	0.2124	0.093	0.0097
14	Diarrhea	BMI		−1235.14	2481.24	−0.677	0.0590	0.078	0.0368
15	CD4	BMI		−1236.28	2483.52	0.001	0.0875	0.093	0.0090
16	Xylose	BMI		−1236.28	2483.52	0.360	0.2178	0.095	0.0131
17	L/M	BMI		−1236.30	2483.56	−2.263	0.2940	0.099	0.0076
18	CLCR	Diarrhea		−1235.39	2481.74	0.010	0.0873	0.897	0.0076
19	CD4	Diarrhea		−1235.53	2482.02	0.001	0.0986	−0.820	0.0155
20	Xylose	Diarrhea		−1236.74	2484.44	0.274	0.3482	−0.845	0.0180
21	L/M	Diarrhea		−1237.16	2485.28	−2.524	0.2961	−0.830	0.0295
22	CLCR	BMI	Diarrhea	−1234.28	2485.00	0.006	0.2692	0.062	0.1129	−0.625	0.0773
23	CD4	BMI	Diarrhea	−1233.82	2484.08	0.001	0.1694	0.069	0.0603	−0.537	0.1321
24	CLCR	CD4	Diarrhea	−1234.80	2486.04	0.009	0.1220	−0.001	0.1280	−0.716	0.0382
25	CLCR	BMI	CD4	−1235.42	2487.28	0.007	0.2440	0.077	0.0394	0.001	0.0845

^*The two models with the smallest BIC