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. Author manuscript; available in PMC: 2007 Sep 25.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2007 Jan 9;34(2):229–249. doi: 10.1007/s10928-006-9043-z

Table II.

Estimated population pharmacokinetic parameters of saquinavir with the two final models

	Model 4		Model 6
	Estimate	SE (CV %)	Estimate	SE (CV %)
exp(μ_CL/F) in L/h	1.26	0.19 (15%)	1.25	0.18 (15%)
β_BMI__CL/F^*	0.11	0.04 (33%) (p-value = 0.0024)
β_DIARRHEA__CL/F^*			−0.98	0.33 (33%) (p-value = 0.0027)
exp(μ_V/F) in L	0.86	0.22 (26%)	0,96	0.24 (25%)
exp(μ_ka) in h⁻¹	0.58	0.05 (9%)	0.61	0,05 (8%)
exp(μ_Tlag) in h	1.13	0.12 (11%)	1.12	0.12 (12%)
ω _CL/F²	1.41	0.30 (22%)	1.38	0.29 (21%)
ω_V/F²	2.43	0.65 (27%)	2.45	0.60 (24%)
ω_ka²	0.22	0.07 (29%)	0.17	0.05 (28%)
ω_Tlag²	0.51	0.13 (25%)	0.53	0.12 (23%)
σ² in (ng/ml)²	85.3	12.5 (15%)	85.7	12.8 (15%)

^*

Effect on log(CL/F)