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. Author manuscript; available in PMC: 2007 Sep 10.
Published in final edited form as: Mol Cell Endocrinol. 2007 Apr 6;271(1-2):55–63. doi: 10.1016/j.mce.2007.04.002

Figure 3. Dlk1-Mediated Repression of GH Promoter Activity Requires Pit-1 Binding Sites.

Figure 3

The left panel depicts a schematic representation of the reporters being tested. Wild type proximal and distal Pit-1 binding sites are depicted as filled squares; mutated sites are depicted as unfilled squares. The names of the reporter vectors tested in order from top to bottom are -500GHp-Luc, -130GHp-Luc, -90GHp-Luc, -70GHp-Luc, d130-65GHp-Luc and -130PmtGHp-Luc. The right panel shows luciferase activities in the absence or presence of co-transfected Dlk1. Values are the mean ± standard deviation of three separate experiments with duplicate samples per experiment. *: P<0.05.