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. Author manuscript; available in PMC: 2007 Sep 10.
Published in final edited form as: Mol Cell Endocrinol. 2007 Apr 6;271(1-2):55–63. doi: 10.1016/j.mce.2007.04.002

Figure 5. Repression of GH Promoter Activity by Dlk1 Deletion Mutants.

Figure 5

The left panel depicts a schematic representation of wild type Dlk1 and Dlk1 deletion constructs. Grey boxes represent the 6 EGF-like domains, the black box represents the juxtamembrane region and the dotted box represents the transmembrane region. The right panel shows luciferase activities in GH3 cells in the absence or presence of cotransfected Dlk1 mutants. The empty vector control is the top bar and set to 1, and the abilities of various Dlk1 mutants to regulate promoter activity are compared to the control. Values are the mean ± standard deviation of three 3 separate experiments with duplicate samples per experiment. *: P<0.05.