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. 2007 Sep 13;117(10):2847–2859. doi: 10.1172/JCI31008

Figure 9. Proinflammatory cytokine and chemokine mRNA profile in the kidney measured by real-time PCR.

Figure 9

mRNA expression of proinflammatory cytokines (IL-6, TNF-α, and IL-1β) and chemokines (MIP-2 and MCP-1) in the kidney was significantly reduced in TLR4–/– (black bars) and MyD88–/– (white bars) mice compared with WT controls (gray bars) from day 1 to day 5 after reperfusion. Results have been normalized by expressing the number of transcript copies as a ratio to GAPDH. Data shown are mean ± SD. n = 6–8 per group. The comparison between TLR4–/– mice or MyD88–/– mice and WT controls is indicated by asterisks. *P < 0.05; **P < 0.01, #P < 0.001.