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. 2007 Sep 13;117(10):2974–2982. doi: 10.1172/JCI31344

Figure 3. Expression of PD-L1 in atherosclerotic lesions.

Figure 3

(A) PD-L1 was detected by immunohistochemistry in aortic sinus lesions of control LDLR–/– mice after 10 weeks of high-cholesterol diet. The same tissues from PD-L1/2–/–LDLR–/– mice did not stain, and served as negative controls. Original magnification, ×400. (B) Two-color immunofluorescence stains for PD-L1 (green) and either CD11c or Mac3 (red) were performed on cholesterol aortic sinus lesions of LDLR–/– mice fed cholesterol-containing diet for 10 weeks. Top: PD-L1 staining alone. Bottom: Combined PD-L1 and MAC3 or PD-L1 and CD11c stains, in which superimposed stains appear yellow.