Table 1.

Laboratory and Clinical Variables in Fifteen Cobalamin Deficient Subjects

Case No.	Age Yr.	Sex	MMA umol/L	tHcy nmol/L	SAM nmol/L	SAH nmol/L	SAM/SAH ratio	Meth umol/L	Cbl pg/ml	Folate* Use +/-	Hct %	Tx Hct† %	MCV FL	Tx MCV‡ FL
1	48	M	13900	197.8	93	58	1.6	9.2	26	-	18.3	50.5	130.3	89.3
2	77	F	12300	134.0	164	66	2.5	14.8	34	-	27.3	34.8	122.5	89.7
3	43	F	8730	76.3	234	59	4.0	14.4	0	+	11.2	38.6	119.2	89.2
4	77	M	6600	119.2	91	36	2.5	31.1	66	-	34.8	38.9	111.7	98.5
5	19	F	3160	70.6	65	26	2.5	13.8	91	-	33.9		104.1
6	58	F	3150	117.3	131	65	2.0	10.3	25	+	18.0	45.1	100.4	82.1
7	40	M	3100	107.0	144	47	3.1	12.9	20	-	18.5	47.5	116.9	86.8
8	38	F	3030	44.3	65	42	1.6	17.2	20	+	20.0		109.6
9	65	M	1880	56.8	104	29	3.6	21.2	89	+	24.6	34.5	56.1	63.4
10	56	F	1810	55.9	94	50	1.9	15.8	82	+	18.7	38.1	128.1	89.6
11	15	F	1550	62.0	96	42	2.3	13.4	0	-	15.7		113.2
12	29	F	1090	55.1	103	41	2.5	13.4	34	+	17.4	41.8	112.0	95.8
13	68	M	833	8.1	222	48	4.6	15.3	212	+	26.6		65.0
14	39	F	373	7.6	104	18	5.8	40.1	185	-	32.9	34.3	75.9	80.5
15	56	M	299	13.5	88	29	3.0	22.2	252	-	38.0		81.2
Mean	48.5		4120	75.0	120	44	2.9	17.7	77		23.7		103.0
(SD)	(19.2)		(4310)	(52.3)	(51)	(14)	(1.2)	(8.2)	(79)		(8.1)		(22.9)
Median	48		3030	62.0	103	42	2.5	14.8	34		20.0		111.7
Reference ranges			(73-271)	(5.4-13.9)	(71-168)	(8-26)	(4.4-12.4)	(13-45)	(>350)		(>36 F)		(80-100)
											(>40 M)

^*Folate use for 1 week to one year prior to metabolite measurements

^†Tx Hct refers to Hct after parenteral cobalamin treatment

^‡Tx MCV refers to MCV after parenteral cobalamin treatment