Table 3.

Mean (SD) Metabolites and Other Variables in Cobalamin Deficient Subjects vs. Those with Other Causes of Anemia

	Cobalamin deficient	Other Anemia		Other Anemia* Normal Renal Status
	N=15	N=19	p†	N=15	p‡
Hematocrit (%)	23.7 (8.1)	27.1 (7.2)	NS§	28.1 (6.6)	NS
MCV (fl)	103.1 (22.9)	87.9 (17.3)	0.035	86 (18)	0.029
Cbl (pg/ml)	77 (79)	666 (512)	<0.001	580 (429)	<0.001
MMA (nmol/L)	4120 (4310)	226 (166)	0.004	225 (187)	0.004
tHcy (umol/L)	75.0 (52.3)	9.4 (4.0)	<0.001	8.6 (3.9)	<0.001
SAM (nmol/L)	120 (51)	127 (62)	NS	104 (40)	NS
SAH (nmol/L)	44 (14)	37 (29)	NS	26 (16)	0.004
SAM/SAH ratio	2.9 (1.2)	4.1 (1.3)	0.008	4.4 (1.2)	0.002

^*The subjects with poor renal function (BUN ≥60) were excluded.

^†p value comparing cobalamin deficient vs Other Anemia by t test.

^‡p value comparing cobalamin deficient vs Other Anemia without the 4 subjects with renal insufficiency.

^§NS refers to not significant.