Table 4.
Mean (SD) Values Pre and Post Cobalamin Treatment in Ten Cobalamin Deficient Patients
| Pre | Post | p* | |
|---|---|---|---|
| Hematocrit (%) | 22.2 (7.5) | 40.4 (5.7) | 0.001 |
| Hemoglobin (g/dL) | 7.5 (2.5) | 14.0 (2.2) | < 0.001 |
| MCV (fl) | 107.3 (23.8) | 86.5 (9.7) | 0.004 |
| White blood cells (x 109/L) | 3.4 (0.9) | 6.0 (3.4) | 0.025 |
| Absolute neutrophil count (x 109/L) | 1.7 (0.6) | 3.6 (2.4) | 0.023 |
| Platelets (x 109/L) | 165 (128) | 219 (66) | 0.092 |
| THcy (umol/L) | 92.7 (53.6) | 7.7 (3.2) | 0.001 |
| MMA (nmol/L) | 5300 (4860) | 154 (63) | 0.009 |
| SAH (nmol/L) | 47 (16) | 25 (11) | 0.001 |
| SAM (nmol/L) | 126 (45) | 114 (41) | 0.563 |
| SAM/SAH (ratio) | 3.0 (1.3) | 4.9 (1.3) | 0.006 |
| Cystathionine (nmol/L) | 886 (363) | 265 (169) | < 0.001 |
| Methylcitric acid (nmol/L) | 1050 (708) | 145 (79) | 0.002 |
| Methionine (umol/L) | 18.3 (9.9) | 23.2 (8.8) | 0.200 |
| N-methylglycine (umol/L) | 1.6 (0.5) | 1.6 (0.6) | 0.747 |
| N, N-dimethylglycine (umol/L) | 5.4 (1.4) | 5.2 (2.5) | 0.766 |
*
p value for paired samples t test is shown.