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Detection of duplication of exons 6b to 10 in the proband. A: DNA sample with no exon deletions or duplications; B: probands’ DNA. A and B: SQF PCR analysis of proband DNA for exon deletions or duplications. Arrows in B indicated duplicated exons. The duplicated fragments included 6b, 7, 8, UpEx 9 (a fragment in IVS8 upstream of exon 9), 9, and 10. The asterisk in the proband’s DNA indicate the detection of ΔF508 mutation, a faster migrating fragment related to exon 10.
