Table 6.
Differential expression between IF patients and drug-resistant cell lines identified 7 up-regulated genes
| Affymetrix code | Drug | Gene name | Description | GO function | Locus |
|---|---|---|---|---|---|
| 216203_at | DNR | SPTLC2 | Serine palmitoyltransferase, long chain base subunit 2 | Biosynthesis | 14q24.3-q31 |
| 218618_s_at | DNR | FAD104 | FAD104 | Hematopoietin/interferon class | 3q26.31 |
| *223380_s_at *227013_at | DNR | LATS2 | LATS, large tumor suppressor, homolog 2 (Drosophila) | Protein serine/threonine kinase activity | 13q11-q12 |
| 207761_s-at | DNR | DKFZ P586A0522 | — | S-adenosylmethionine-dependent methyltransferase activity | 12q13.13 |
| †226550_at | DNR, ASP | — | FLJ39602 | — | Xp11.3 |
| 218847_at | ASP | IMP2 | IGF-II mRNA-binding protein 2 | Translational attenuation; morphogenesis; RNA binding | 3q28 |
| 235824_at | ASP | EST | Homo sapiens transcribed sequences | — | — |
— indicates not applicable.
*
Shared probesets for LATS2.
†
Probeset shared between DNR and ASP-resistant cell lines.