Table 2.
Psychiatric outcome of subjects prenatally exposed to DES and their unexposed siblings
| Subjects with prenatal DES exposure n (%) | Siblings without prenatal DES exposure n (%) | Adjusted OR (95% CI)a | |
|---|---|---|---|
| Suicide | 9 (0.5) | 7 (0.5) | |
| Psychiatric hospitalization | 60 (3.6) | 55 (3.8) | |
| Strictly defined serious psychiatric outcomeb | 60 (3.6) | 58 (4) | 0.8 (0.5–1.2), p = 0.22 |
| Consultation with a psychiatrist | 194 (11.6) | 147 (10.2) | |
| Consultation with a psychologist | 199 (11.9) | 162 (11.2) | |
| Broadly defined serious psychiatric outcomec | 330 (19.6) | 267 (18.5) | 1.0 (0.8–1.2), p = 0.86 |
DES, Diethylstilboestrol; OR, odds ratio; CI, confidence interval.
a
Adjusted for duration of follow-up, educational level, history of at least one definite obstetric complication according to the Lewis and Murray scale (Lewis & Murray, 1987) (see Table 1), prenatal exposure to progestagen drugs or other hormones, paternal or maternal history of psychiatric hospitalization.
b
Suicide or psychiatric hospitalization.
c
Suicide, psychiatric hospitalization or consultation with a psychiatrist or a psychologist.