Skip to main content
. 2007 Sep 5;104(37):14825–14830. doi: 10.1073/pnas.0705046104

Fig. 3.

Fig. 3.

Differences in vulnerability to excitotoxicity between both rat strains in vivo. (A) Motor score after spinal cord ischemia [0 = normal, 6 = complete paraplegia (18); n = 6–8; *, P < 0.05, different from Wistar]. (B and C) H&E staining of spinal cord section after spinal cord ischemia induced by clamping of the aortic arch and left subclavian artery for 14 min from a Wistar rat (B) and a Holtzman rat (C). gm, gray matter; wm, white matter. (Scale bar, 50 μm.) Quantification of number of neurons (divided into three size categories) in the ventral horn of the lumbar spinal cord after spinal cord ischemia, with or without pretreatment with the AMPA receptor antagonist, NBQX (n = 4–8; *, P < 0.05). Survival of Wistar and Holtzman mt SOD1 rats (n = 55–62 per group). Quantification of number of neurons (divided into three size categories) in the ventral horn of the lumbar spinal cord of end-stage Wistar and Holtzman mt SOD1 rats (n = 3; P > 0.3).