Table 1.
Serum pharmacokinetic parameters of [3H]-CpG-ODN, DNP-[3H]-CpG-ODN, and DNP2-[3H]-CpG-ODN following a single intravenous bolus injection into DNP-immunized, tumor-bearing mice.
| [3H]-CpG-ODN* | DNP-[3H]-CpG-ODN | DNP2-[3H]-CpG-ODN | |
|---|---|---|---|
| t1/2,β (hr) | 0.694 ± 0.745 | 185 ± 95.8 (266
 )†
|
74.6 ± 15.0 (108
) |
| AUC (hr·μg/ml) | 1.46 ± 0.903 | 2410 ± 1120 (1650
) |
1290 ± 214 (884
) |
| V1 (ml) | 1.75 ± 0.131 | 1.54 ± 0.172 | 1.60 ± 0.167 |
| V2 (ml) | 8.46 ± 6.24 | 0.657 ± 0.234 (12.9
 ) |
0.228 ± 0.194 (37.0
) |
| CL (ml/hr) | 12.6 ± 7.85 | 0.00825 ± 0.00385 (1530
) |
0.0170 ± 0.00281 (746
) |
| MRT (hr) | 0.807 ± 0.949 | 267 ± 138 (331
) |
108 ± 21.6 (134
) |
*
In non-immunized, tumor-bearing mice; control ODN is shaded gray
†
Fold-change relative to control ODN. Arrows indicate direction of change