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. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Prog Lipid Res. 2006 Dec 21;46(2):89–107. doi: 10.1016/j.plipres.2006.11.001

Fig 1.

Fig 1

Structures of LR isoforms. All isoforms are products of splicing variants of a single transcript. Each isoform has a conserved region, and may or may not have a variable region. The conserved region forms the extracellular and transmembrane domains as well as a small portion of the intracellular domain; the aminoacid sequence of this region is always constant, although it may be truncated. The variable region forms a large portion of the intracellular domain; the aminoacid sequence in this region is highly sensitive to splicing. The first or last aminoacid of each region and domain are listed at the first (left to right) diagram that contains this region or domain; amino acid numbering is based on the published sequences of mouse LRa-e [23,24] and rat LRf[25]. Box motifs for JAK-STAT phosphorylation are marked. Only when two JAK-STAT box motifs are present (as in LRb) does LR display full signal transduction capability.