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. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Prog Lipid Res. 2006 Dec 21;46(2):89–107. doi: 10.1016/j.plipres.2006.11.001

Fig. 5.

Fig. 5

Concentrations of TNF-α and corticosterone in the plasma of Koletsky f/f rats and their wild-type (F/?) counterparts 120 min after intravenous administration of LPS (100 μg/kg) or saline in a cool environment. This time point (120 min) corresponds to the maximal rate of divergence between the hypothermic responses of the f/f and F/? rats shown in Fig. 4. These data suggest that the exaggerated hypothermia of Koletsky f/f rats is associated with an enhanced rise in plasma TNF-α and a lack of activation of the HPA axis. Adapted from Ref. 110 by permission from the Federation of American Societies for Experimental Biology.