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The effect of systemic prazosin administration on the locomotor response to 2 mg/kg (+)-amphetamine. Pretreatment with 0.5 or 1.0 mg/kg prazosin produced a significant overall effect on the locomotor response to (+)-amphetamine (F(2,12) = 12.63; p < 0.01). Significant deceases in (+)-amphetamine-induced hyperactivity were observed in animals pretreated with 0.5 mg/kg (* p < 0.05) and 1.0 mg/kg (**p < 0.01) of prazosin. Number of animals used for each treatment n = 6.
