Table 10.
Intracellular messaging-related significant genesa
| Entrez gene | Gene symbol | Gene name | QTL | Combined regions fold (iP vs. iNP) | Individual regionb significant in (fold) |
|---|---|---|---|---|---|
| Decreased expression (iP vs. iNP) | |||||
| 66013 | Arhgef9 | Cdc42 guanine nucleotide exchange factor (GEF) 9 | -1.22 | ||
| 114851 | Cdkn1a | cyclin-dependent kinase inhibitor 1A | -1.11 | ||
| 171109 | Dusp5 | dual specificity phosphatase 5 | -1.07 | ||
| 116663 | Dusp6 | dual specificity phosphatase 6 | -1.28 | ||
| 25114 | Fgfr4 | fibroblast growth factor receptor 4 | -1.09 | ||
| 25661 | Fn1 | fibronectin 1 | -1.27 | ||
| 24416 | Grm3 | glutamate receptor, metabotropic 3 | -1.31 | ||
| 25589 | Kdr | kinase insert domain protein receptor | -1.28 | AMYG (-1.50) | |
| 24592 | Nf1 | neurofibromatosis 1 | -1.16 | ||
| 29353 | Phkg1 | phosphorylase kinase gamma 1 | Alc10 | -1.08 | |
| 29583 | Pecam | platelet/endothelial cell adhesion molecule | -1.14 | ||
| 29340 | Prkce | protein kinase C, epsilon | Alc17 | -1.29 | |
| 84014 | Ralbp1 | ralA binding protein 1 | -1.11 | ||
| 24718 | Reln | reelin | -1.14 | ||
| 24794 | Spin2b | Serine protease inhibitor | Alc17 | -1.07 | |
| 361813 | Stk38 | serine/threonine kinase 38 | -1.17 | ACB (e1.37), CPU (e1.21) | |
| 192117 | Syngap1 | synaptic Ras GTPase activating protein 1 homolog (rat) | -1.15 | ||
| Increased expression (iP vs. iNP) | |||||
| 25673 | Anxa5 | annexin A5 | 1.10 | ||
| 83839 | Calb1 | calbindin 1 | Alc4 | 1.16 | |
| 24242 | Calm1 | calmodulin 1 | Alc17 | 1.07 | |
| 25420 | Cryab | crystallin, alpha B | 1.32 | CPU (1.35) | |
| 83633 | Gpr51 | G protein-coupled receptor 51 | Alc4 | 1.12 | |
| 155918 | LCPU2 | lymphocyte cytosolic protein 2 | Alc9 & 12 | AMYG (1.18) | |
| 59322 | Cnksr2 | membrane-associated guanylate kinase-interacting protein | 1.08 | ||
| 58840 | Mapk6 | mitogen-activated protein kinase 6 | 1.08 | ||
| 24605 | Nras | neuroblastoma ras oncogene | 1.07 | ||
| 84587 | Plcl1 | phospholipase C-like 1 | 1.14 | ||
| 54705 | Ppm2c | protein phosphatase 2C, magnesium dependent, catalytic subunitc | Alc4 | 1.13 | |
| 29645 | Ptprj | protein tyrosine phosphatase, receptor type, J | 1.28 | ||
| 64373 | Rhob | rhoB gene | Alc17 | 1.10 | |
iP = inbred alcohol-preferring rat; iNP = inbred alcoholenon-preferring rat.
Defined as categorized by a Gene Ontology category (small GTPase mediated signal transduction, negative regulation of protein kinase activity, negative regulation of enzyme activity, transmembrane receptor protein tyrosine kinase signaling pathway) or were found through manual curation to have an intracellular messaging-related function (Anxa5, Calb1, Calm1, Dusp5, Dusp6, Cnksr2, Mapk6, Nf1, Plcl1, Phkg1, Prkce, Ppm2c, Ppm2c, Spin2b, Stk38, Syngap1).
ACB = nucleus accumbens, AMYG = amygdala, FC = frontal cortex, HIPP = hippocampus, CPU = caudate-putamen.
Gene represented by more than one significant probe set. Largest of the multiple fold changes is reported in column 5.