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Model for E8 and MC159 inhibition of Fas and TNFR1 signaling pathways. Fas and TNFR1 cell surface receptors induce apoptosis through the binding of FADD to the prodomain of caspase-8. E8 and MC159 proteins bind to the caspase-8 prodomain and FADD, respectively, and may block Fas- and TNFR1-induced apoptosis by interfering with the ability of pro-caspase-8 to bind to FADD. In contrast, CrmA and P35 antiapoptotic proteins directly inhibit caspase-8 enzymatic activity.
