Table 1.

Platelet counts and human PF4 levels in inflammatory models in hPF4⁺ mice

Injection	Drop in platelet count, % of baseline	PF4 plasma level, kU/mL	PF4 level in lungs, U/mg protein
PBS, 200 μL IV	92 ± 11	3.65 ± 1.30	583 ± 271
Thrombin, 80 U/kg IV	72 ± 11*	7.67 ± 1.00†	1087 ± 99†
PBS, 200 μL IP	100 ± 17	2.57 ± 0.90	656 ± 120
LPS, 40 mg/kg IP	75 ± 13*	3.05 ± 0.77	991 ± 218†

Mice (n = 4-6 per arm) were injected with either phosphate-buffered saline (PBS), 80 U/kg thrombin or 40 mg/kg LPS. Compared are results of PBS solute only (200 μL/mouse) 10 minutes after thrombin (80 U/kg in 200 μL IV) and 2 hours after LPS (40 mg/kg in 200 μL IP). The means (± 1 SD) are shown. Statistical analysis between groups was performed using the Student t test (A-C). Note: Platelets release PF4 in vivo after either thrombin or LPS injection into mice.

^*P < .04 compared with simultaneous studies of PBS controls.

^†P < .02 compared with simultaneous studies of PBS controls.