Table 3.

Clinical outcome for 18 adults with refractory acute leukemia treated with clofarabine followed by cyclophosphamide

Clofarabine dose	n	No. patients (%)
		CTC day 14*	CR	PR	NE	NR	Overall response
Dose level 1, 20 mg/m2	6
AML	3	1 (33)	0	1 (33)	2 (67)	0	1 (33)
ALL	3	3 (100)	2 (67)	0	0	0	2 (67)
Total	NA	4 (67)	2 (33)	1 (17)	2 (33)	0	3 (50)
Dose level 0, 10 mg/m2	12
AML	9	6 (67)	2 (22)	0	2 (22)	5 (56)	2 (22)
ALL	3	1 (33)	1 (33)	1 (33)	0	1 (33)	2 (67)
Total	NA	7 (58)	3 (25)	1 (8)	2 (8)	6 (50)	4 (33)

NE indicates not evaluable; NA, not applicable; and NR, no response.