Table 4.

In vivo effects of clofarabine on cyclophosphamide-induced DNA damage and apoptosis in peripheral blood blasts

	Day 0, CY alone		Day 1, clofarabine → CY, 2 h after end of infusion
	End of infusion	2 h after end of infusion
Fold increase in γH2AX relative to pretreatment
Median	1.6	0.7	5.7
Range	0.4-6.2	0.6-6.8	0.3-38
No. of 1.5-fold or greater increase (%)	5/13 (38)	3/13 (23)	12/13 (92)
No. of 3-fold or greater increase (%)	2/13 (15)	1/13 (8)	7/13 (54)
Fold increase in cells with sub-2N DNA content
Median	1.3	1.2	1.6
Range	0.5-52	0.4-90	0.2-62
No. of 1.5-fold or greater increase (%)	3/13 (23)	4/13 (32)	8/13 (62)

Where applicable, data are no./total no. of patients in that category.