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Single-channel open probability (Po(0)) of wild-type and Kir6.2-F333I mutant channels
| Po(0) | ||
|---|---|---|
| SUR subtype | Kir6.2 | Kir6.2-F333I |
| SUR1 | 0.35 ± 0.04 (n = 7) | 0.38 ± 0.08 (n = 7) |
| SUR2A | 0.40 ± 0.06 (n = 6) | 0.71 ± 0.04 (n = 7)* |
| SUR2B | 0.41 ± 0.08 (n = 4) | 0.68 ± 0.06 (n = 6)* |
Mean ± s.e.m. values of intrinsic open probability (Po(0)) measured at −60 mV.
Statistical significance against the wild-type (P < 0.05). The number of patches is indicated in parentheses.
