TABLE 1.
THE BASELINE CHARACTERISTICS OF STUDY SUBJECTS ACROSS QUARTILES OF EXPANDED LUMEN RATIO
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P Value | |
|---|---|---|---|---|---|
| No. of patients | 25 | 25 | 26 | 25 | — |
| Lumen content of expanded airway, % | 1.1 ± 0.2* | 3.8 ± 0.1 | 7.0 ± 0.3† | 18.4 ± 2.0‡ | <0.001 |
| No. of airways examined per case | 6.8 ± 1.7* | 9.7 ± 1.7 | 13.9 ± 2.5 | 5.3 ± 0.9* | 0.006 |
| No. of male subjects (%) | 13 (52) | 14 (56) | 16 (62) | 16 (64) | 0.823 |
| Age, yr | 64 ± 2 | 66 ± 1 | 68 ± 1 | 66 ± 1 | 0.255 |
| Smoking, pack-years | 55 ± 6 | 58 ± 5 | 68 ± 4 | 68 ± 6 | 0.255 |
| BMI, kg/m2 | 25.1 ± 0.9 | 24.8 ± 0.7 | 25.3 ± 0.8 | 25.8 ± 1.0 | 0.869 |
| FEV1, % predicted | 28.0 ± 1.4 | 24.2 ± 1.3 | 28.0 ± 1.5 | 26.0 ± 1.5 | 0.191 |
| FVC, % predicted | 66.4 ± 4.2 | 62 ± 3.3 | 69.3 ± 3.2 | 67.0 ± 2.7 | 0.501 |
| RV, % predicted | 217 ± 11 | 249 ± 11† | 202 ± 6 | 215 ± 11.6 | 0.012 |
| DlCO, % predicted | 26.8 ± 2.1 | 28.7 ± 1.9 | 28.5 ± 1.9 | 28.9 ± 1.6 | 0.884 |
| PaO2, mm Hg | 63.0 ± 1.7 | 60.9 ± 2.1 | 58.6 ± 2.3 | 59.6 ± 1.6 | 0.468 |
| WBC, 103/mm3 | 7.97 ± 0.52 | 7.63 ± 0.48 | 8.38 ± 0.44 | 8.02 ± 0.50 | 0.732 |
| SF-36 PCS | 30.9 ± 1.6 | 29.2 ± 1.4 | 28.6 ± 2.0 | 28.6 ± 1.8 | 0.789 |
| SF-36 MCS | 60.6 ± 1.1 | 56.6 ± 1.2 | 57.2 ± 1.8 | 55.6 ± 1.8 | 0.189 |
| QWB score | 0.59 ± 0.02 | 0.60 ± 0.02 | 0.54 ± 0.02 | 0.57 ± 0.03 | 0.227 |
| SGRQ overall score | 46.5 ± 2.5 | 55.4 ± 2.7 | 50.5 ± 2.5 | 51.2 ± 3.0 | 0.173 |
| UCSD SOBQ | 53.9 ± 4.0 | 65.9 ± 2.6 | 59.0 ± 4.0 | 63.2 ± 4.3 | 0.152 |
| Six-minute-walk, ft | 1,234 ± 60 | 1,295 ± 52 | 1,274 ± 62 | 1,308 ± 71 | 0.867 |
| Wall thickness, mm | 0.138 ± 0.007 | 0.151 ± 0.007 | 0.142 ± 0.005 | 0.171 ± 0.008*† | 0.004 |
| Epithelial thickness, mm | 0.033 ± 0.002 | 0.034 ± 0.002 | 0.032 ± 0.001 | 0.039 ± 0.002 | 0.103 |
| Lamina propria, mm | 0.037 ± 0.002 | 0.042 ± 0.002 | 0.040 ± 0.002 | 0.040 ± 0.002 | 0.446 |
| Smooth muscle, mm | 0.016 ± 0.001 | 0.018 ± 0.001 | 0.020 ± 0.001 | 0.021 ± 0.001† | 0.027 |
| Adventitia, mm | 0.070 ± 0.005 | 0.073 ± 0.004 | 0.068 ± 0.005 | 0.092 ± 0.006*† | 0.006 |
| Airways with lymphoid follicles, % | 20.8 ± 5.7 | 30.4 ± 3.8 | 20.7 ± 3.0 | 33.9 ± 6.8 | 0.155 |
Definition of abbreviations: BMI = body mass index; DlCO = diffusion capacity of the lung for carbon monoxide; MCS = Mental Component Summary score; PCS = Physical Component Summary score; QWB = Quality of Well-Being scale; SF-36 = Short Form-36; SGRQ = St. George's Respiratory Questionnaire; UCSD SOBQ = University of California, San Diego, Shortness of Breath Questionnaire; WBC = white blood cell count.
Values are mean ± SEM.
*
Different from quartile 3 at P < 0.05.
†
Different from quartile 1 at P < 0.05.
‡
Different from all the other quartile groups at P < 0.05.