TABLE 2.

COMPARISON OF UNTREATED AND CORTICOSTEROID-TREATED GROUPS

Parameter	Nontreated (n = 16)	Inhaled Steroids (n = 45)	Oral ± Inhaled Steroids (n = 33)	P Value
Demographics
Age, yr	65 ± 2	68 ± 1	64 ± 1*	0.061
BMI, kg/m2	26.3 ± 1.1	25.4 ± 0.6	24.6 ± 0.8	0.402
Smoking, pack-years	64 ± 8	64 ± 4	61 ± 5	0.882
Physiology
FEV1, % predicted	27.9 ± 2.1	26.7 ± 0.9	25.2 ± 1.4	0.420
TLC, % predicted	128.3 ± 3.8	129.8 ± 2.0	128.3 ± 2.9	0.837
DlCO, % predicted	30.4 ± 2.4	28.1 ± 1.4	27.7 ± 1.5	0.602
Six-minute-walk, ft	1,399 ± 66	1,334 ± 45	1,146 ± 47*†	0.004
Reduced maximum load (⩽ 40 W for men; ⩽ 25 W for women)	13%	37%	48%	0.256
PaO2, mm Hg	64.3 ± 2.2	58.2 ± 1.4	61.4 ± 1.7	0.139
WBC, 103/mm3	7.2 ± 0.3	7.3 ± 0.3	9.5 ± 0.4*†	<0.001
Symptoms and health status
UCSD SOBQ	63.9 ± 3.0	55.0 ± 2.8	67.1 ± 3.3*	0.012
SF-36 PCS	27.7 ± 1.6	31.9 ± 1.3	26.2 ± 1.3*†	0.007
SF-36 MCS	57.9 ± 2.2	58.4 ± 0.8	55.4 ± 1.7	0.233
QWB	0.60 ± 0.02	0.61 ± 0.02	0.51 ± 0.02*†	<0.001
SGRQ overall score	51.2 ± 2.5	47.4 ± 2.0	56.0 ± 2.3*	0.016
Small airway wall dimensions
Lumen content of collapsed airway, %	32.4 ± 3.9	30.2 ± 3.0	30.4 ± 3.8	0.931
Lumen content of expanded airway, %	8.20 ± 1.73	8.02 ± 1.13	7.89 ± 1.76	0.993
Airways containing lymphoid follicles, %	40.2 ± 6.4	26.1 ± 3.7	21.3 ± 4.5†	0.051
Total wall thickness, mm	0.16 ± 0.008	0.15 ± 0.005	0.15 ± 0.006	0.913
Epithelial thickness, mm	0.035 ± 0.003	0.035 ± 0.001	0.035 ± 0.002	0.971
Lamina propria, mm	0.041 ± 0.002	0.040 ± 0.002	0.040 ± 0.002	0.801
Smooth muscle, mm	0.020 ± 0.001	0.018 ± 0.001	0.019 ± 0.001	0.320
Adventitia, mm	0.078 ± 0.006	0.077 ± 0.004	0.078 ± 0.005	0.971

For definition of abbreviations, see Table 1.

Values are mean ± SEM.

^†P < 0.05 versus nontreated group.

^*P < 0.05 versus inhaled steroids group.