TABLE 3.
SELECTED GENES UP-REGULATED IN THE LUNGS OF mmp12-/- MICE, COMPARED WITH WILD-TYPE MICE (DAY 7 AFTER THREE CONSECUTIVE INSTILLATIONS OF Jo2 mAb)
| Gene | Name | Fold Change | P Value | Biological Process |
|---|---|---|---|---|
| hsp105 | Heat shock protein 105 | 5.06 | 0.01991 | Protein folding |
| ctse | Cathepsin E | 4.76 | 0.0474 | Proteolysis |
| mela | Melanoma antigen | 2.17 | 0.02564 | — |
| dnaja1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 2.13 | 0.04941 | Protein folding-response to heat |
| herpud1 | Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 2.07 | 0.01719 | Response to stress |
| cd59a | CD59a antigen | 1.98 | 0.02527 | — |
| stip1 | Stress-induced phosphoprotein 1 | 1.95 | 0.00519 | Response to stress |
| klf9 | Kruppel-like factor 9 | 1.9 | 0.04292 | Embryo implantation |
| xlkd1 | Extra cellular link domain-containing 1 | 1.7 | 0.02760 | Glycosaminoglycan catabolism |
| angptl4 | Angiopoietin-like 4 | 1.69 | 0.03166 | Negative regulation of apoptosis |
| tinagl | Tubulointerstitial nephritis antigen-like | 1.62 | 0.01896 | Proteolysis |
| hspa8 | Heat shock protein 8 | 1.61 | 0.02328 | Regulation of cell cycle |
| fkbp4 | FK506 binding protein 4 | 1.59 | 0.00741 | Protein folding |
| hspa5 | Heat shock 70kD protein 5 | 1.52 | 0.02266 | ER-overload response |
| cryaa | Crystallin, alpha A | 1.51 | 0.03559 | M-phase microtubule process |
| sox7 | SRY-box containing gene 7 | 1.46 | 0.04429 | Regulation of transcription |
| carhsp1 | Calcium regulated heat stable protein 1 | 1.45 | 0.03151 | Regulation of transcription |
| alas1 | Aminolevulinic acid synthase 1 | 1.45 | 0.04172 | Heme biosyntesis |
| timp3 | Tissue inhibitor of metalloproteinase 3 | 1.4 | 0.01070 | — |
| eif4a2 | Eukaryotic translation initiation factor 4A2 | 1.34 | 0.02850 | Protein biosynthesis |
Definition of abbreviation: mAb, monoclonal antibody.