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. 2007 Sep 18;5(10):e246. doi: 10.1371/journal.pbio.0050246

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© 2007 Cummings et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) sIgM loss fluctuation assay of panels of independent DT40 PolyLacO-Vλ_R GFP-LacI (n = 27) and DT40 PolyLacO-Vλ_R LacI-HP1 (n = 16). The figure shows combined data from at least two independent transfectants for each fusion construct. Median diversification rates are shown below.

(B) Summary of sequence analysis of Vλ regions carrying unique mutations from DT40 PolyLacO-Vλ_R GFP-LacI (n = 71) and DT40 PolyLacO-Vλ_R LacI-HP1 (n = 36) transfectants, as analyzed by single-cell PCR. Sequences were pooled from two independent transfectants.