Figure 2.

Confocal analysis of double immunofluorescence in CHO cells stained for the HCV core and the nuclear membrane marker lamin B. (a Upper) Horizontal sections of 0.5 μm each of two cells with the core protein in the nucleus. (Lower) Vertical sections of 0.3 μm of the same cells. The core protein is visible on the cytoplasmic site of the nuclear membrane and has been never found in the nucleus. (b) Explanation of the pseudo-nuclear localization of the core protein. Shown from left to right are superposition of all the slices: the core protein seems to be in the nucleus; successive slices from the bottom of the cell: the core protein is in the cytoplasm and lies in a nuclear invagination.