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. 1992 Nov;66(5):787–793. doi: 10.1038/bjc.1992.361

Cholesterol metabolism during the growth of a rat ascites hepatoma (Yoshida AH-130).

S Dessí 1, B Batetta 1, C Anchisi 1, P Pani 1, P Costelli 1, L Tessitore 1, F M Baccino 1
PMCID: PMC1977989  PMID: 1419621

Abstract

The metabolism of cholesterol has been investigated in tumour cells, ascitic fluid and blood serum during the growth of an ascites hepatoma (Yoshida AH-130) in the rat. High rates of cholesterol synthesis and elevated free and esterified cholesterol content were observed in tumour cells. During tumour growth, the host animals progressively developed marked changes in the level and distribution of serum cholesterol consisting in an increase of total cholesterol and of a marked reduction of HDL cholesterol (HDL2 subfraction in particular). In agreement with previous observations, these findings indicate that a consistent pattern of altered cholesterol homeostasis develops in relation to normal or neoplastic tissue growth. High synthetic rates and intracellular accumulation of cholesterol are observed in the proliferating cells. Moreover, blood serum cholesterol decreases in the HDL fraction while it increases in LDLs, suggesting that during proliferative processes cholesterol fluxes between tissues and serum lipoproteins are markedly perturbed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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