. Author manuscript; available in PMC: 2007 Nov 1.

Published in final edited form as: Ageing Res Rev. 2007 Feb 20;6(1):28–45. doi: 10.1016/j.arr.2007.02.005

Table -1.

Phenotypic characteristics of GH/IGF-1/Insulin long-living mutant mice.

Phenotype	AMES, SNELL (prop-1, pit-1) Schaible & Gowen, 1961; Snell, 1929	GHR/BP KO Zhou et al., 1997	IGF-1R +/− Holzenberger et al., 2003	KLOTHO Kurosu et al., 2005
GH/IGF1 signaling
Body size
Reproduction
Insulin sensitivity			Partial IGF-1 resistance	Insulin & IGF-1 resistance
Stress resistance
Longevity	35-70%, 42%	42-55%	26%	18-30%