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. Author manuscript; available in PMC: 2008 Apr 30.
Published in final edited form as: Cancer Cell. 2007 May;11(5):447–460. doi: 10.1016/j.ccr.2007.03.009

Figure 1. ERK signaling affects c-Jun expression.

Figure 1

A. Levels of P-ERK, P-JNK and proteins relevant to the PKC/JNK pathway in melanoma cell lines. Protein extracts (40μg) from melanoma cell lines were analyzed by Western blots using the indicated antibodies. Human melanocytes (HuMel) were used as a control. α-Tubulin reveals equal loading.

B. Inhibition of B-Raf reduces c-Jun levels. Lu1205 cells were treated with 300nM CHR-265 for 6h and 24h. Protein samples were analyzed by Western blots using the indicated antibodies. α-Tubulin reveals equal loading.

C. Inhibition of the MEK/ERK pathway reduces c-Jun levels. A375 cells were treated with 50μM PD98059 and 20μM U0126 for 24h. Protein samples were analyzed by Western blots using the indicated antibodies.