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. Author manuscript; available in PMC: 2007 Sep 17.
Published in final edited form as: Neuroscience. 2007 Apr 16;146(3):1316–1332. doi: 10.1016/j.neuroscience.2007.03.003

Table 3.

Plasma Antipsychotic Levels

Test Group Dose/24 hr Compound Measured Plasma Concentration (ng/mL )± S.E.M.
N=6-12		 Estimated Human Therapeutic
Plasma Range (ng/mL)*
15 Days 90 days 180 days
haloperidol 2.0 mg/kg haloperidol 6.4 ± 0.9 11.5 ± 2.4 12.4 ± 2.8 4.0-18.0
risperidone 2.5 mg/kg risperidone 4.7 ± 1.3 7.4 ± 2.8 4.3 ± 1.6
9-OH risperidone 22.5 ± 3.5 30.2 ± 8.8 22.8 ± 7.4
risperidone +
9-OH risperidone		 27.2 ± 4.6 37.5 ± 11.5 27.1 ± 8.9 20.0-60.0
*

Estimated human therapeutic plasma ranges listed are based on Baldessarini et al., 1988; Markowitz and Patrick, 1996; Coryell et al., 1998; Balant-Gorgia et al., 1999.