Table 3.

Hazard rate ratio between T-786C and E298D polymorphisms and risk of incident CHD or stroke

	Caucasian			African-American
Polymorphism	HRR	95% CI	P-value	HRR	95% CI	P-value
CHD
E298D	G/T + T/T versus G/G			G/T + T/T versus G/G
Model 1a	0.94	0.75−1.17	P=0.586	0.87	0.57−1.34	P=0.526
Model 2b	1.03	0.80−1.33	P=0.819	0.66	0.40−1.09	P=0.105
T-786C	T/C + C/C versus T/T			T/C + C/C versus T/T
Model 1a	1.13	0.90−1.42	P=0.210	0.80	0.52−1.20	P=0.279
Model 2b	1.24	0.96−1.62	P=0.106	0.83	0.53−1.31	P=0.421
Stroke
E298D	G/T + T/T versus G/G			G/T + T/T versus G/G
Model 1a	0.94	0.65−1.36	P=0.742	1.50	0.89−2.53	P=0.133
Model 2c	0.97	0.65−1.44	P=0.884	1.35	0.76−2.41	P=0.311
T-786C	T/C + C/C versus T/T			T/C + C/C versus T/T
Model 1a	1.06	0.72−1.55	P=0.783	1.70	1.05−2.75	P=0.032
Model 2c	1.09	0.73−1.64	P=0.665	1.63	0.93−2.88	P=0.090

CHD, coronary heart disease; HRR, hazard rate ratio; CI, confidence interval.

^aAdjusted for age, sex, and study center.

^bAdjusted for age, sex, study center, current smoker, diabetes, hypertension, HDL cholesterol, total cholesterol, and body mass index.

^cAdjusted for age, sex, study center, current smoker, diabetes, and hypertension.