Table 4.

E298D genotype by smoking interaction and risk of incident CHD and stroke^a,b

	Caucasian			African-American
Smoking exposure	E298D genotype		Interactionc	E298D genotype		Interactionc
CHDd	G/G n = 365/279	G/T + T/T n = 416/335		G/G n = 182/241	G/T + T/T n = 44/70
Current smoker
No	1 (referent)	0.83 (0.61−1.13)	2.10 (1.17−3.76)	1 (referent)	0.63 (0.34−1.16)	1.17 (0.43−3.18)
Yes	1.19 (0.77−1.83)	2.07 (1.39−3.07)	P=0.013	1.90 (1.17−3.10)	1.40 (0.62−3.18)	P=0.762
Pack-years
< 20 years	1 (referent)	0.84 (0.61−1.17)	1.50 (0.89−2.53)	1 (referent)	0.61 (0.35−1.06)	1.30 (0.43−3.90)
≥ 20 years	1.23 (0.83−1.83)	1.56 (1.08−2.24)	P=0.126	1.19 (0.73−1.93)	0.94 (0.35−2.50)	P=0.641
Strokee	G/G n = 70/296	G/T + T/T n = 80/363		G/G n = 85/254	G/T + T/T n = 30/68
Current smoker
No	1 (referent)	0.81 (0.51−1.30)	1.70 (0.71−4.06)	1 (referent)	1.26 (0.57−2.77)	1.24 (0.37−4.19)
Yes	1.58 (0.83−3.00)	2.18 (1.19−3.99)	P=0.234	2.00 (1.08−3.69)	3.12 (1.22−7.99)	P=0.726
Pack-years
< 20 years	1 (referent)	0.80 (0.46−1.38)	1.48 (0.66−3.31)	1 (referent)	1.36 (0.67−2.74)	1.00 (0.25−4.01)
≥ 20 years	1.49 (0.81−2.75)	1.77 (0.98−3.21)	P=0.337	1.39 (0.70−2.75)	1.88 (0.53−6.62)	P=0.999

CHD, coronary heart disease; HRR, hazard rate ratio; CI, confidence interval.

^aNumber of cases/noncases in each genotype cell.

^bData presented as HRR (95% CI).

^cMultiplicative E298D by smoking interaction term HRR (95% CI), and P-value.

^dAdjusted for age, sex, study center, diabetes, hypertension, HDL cholesterol, total cholesterol, and body mass index.

^eAdjusted for age, sex, study center, diabetes, and hypertension.