. Author manuscript; available in PMC: 2008 Aug 1.

Published in final edited form as: Exp Parasitol. 2007 Feb 13;116(4):346–353. doi: 10.1016/j.exppara.2007.01.022

Table 4.

In vivo inhibition of P. falciparum oocyst formation by gomesin

Gomesin concentration	Oocysts per Midgut^a	Oocyst-positive mosquitoes^b	% Oocyst inhibition
control	23±23 (0–99)	78.8 (41/52)	-
25 μM	17±21 (0–89)^*	63.4 (33/52)	26
50 μM	10±12 (0–51)^**	71.2 (37/52)	56
100 μM	0.5±1.2 (0–5)^**	25 (13/52)	99.9
200 μM	0^**	0 (0/52)	100

P. falciparum stage V gametocytes mixed with gomesin were membrane fed to An. stephensi mosquitoes. Mosquitoes were kept at 26°C and the number of oocysts per midgut was determined on day 8.

Mean oocyst number per mosquito midgut. The range of observed values is indicated in parentheses.

Percentage of mosquitoes that had oocysts in their midgut. These values were derived from the number of oocyst-positive mosquitoes over the total number of mosquitoes examined (shown in parentheses).

p<0.05;

^**

p<0.0001 in comparison to the control by the t- test.