Table 2.
Model parameters
| Name | Description (units) | Determination | Value |
|---|---|---|---|
| k12 | Extravasation (min−1) | Fit to data | 3.1 × 10−4 |
| k21 | Return to blood (min−1) | Varied | |
| k23 | Binding to or uptake by tumor cells (min−1) | Varied | |
| k32 | Release from binding (min−1) | Estimated from ref. 27, mAb/TfR | 7 × 10−3 |
| kelim | Rate of elimination from blood (min−1) | Estimated from data in Fig. 2 | 0.14 |
| V1 | Plasma volume, mouse (L) | Estimated from ref. 28 | 1.5 × 10−3 |
| V2 | Tumor interstitial volume (L) | Estimated from ref. 29, 300 mm3 tumor | 1.1 × 10−4 |
| V3 | Tumor cellular volume (L) | Estimated from ref. 29, 300 mm3 tumor | 1.8 × 10−4 |
| Vtv | Tumor vascular volume (L) | Estimated from ref. 29, 300 mm3 tumor | 1.5 × 10−5 |