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. Author manuscript; available in PMC: 2008 Jun 1.
Published in final edited form as: Sleep Med. 2007 Apr 30;8(4):373–399. doi: 10.1016/j.sleep.2007.03.008

Fig. 5. (a) CSF hypocretin-1 levels in narcoleptic and control subjects. (b) Preprohypocretin mRNA in situ hybridization in the hypothalamus of control and narcoleptic subjects.

Fig. 5

(a) CSF hypocretin-1 levels are undetectably low in most narcoleptic subjects (84.2%). Note that two HLA DqB1*0602-negative and one familial case have normal or high CSF hypocretin levels. (b) Preprohypocretin transcripts are detected in the hypothalamus of control (B) but not narcoleptic subjects (A). Melanin-concentrating hormone (MCH) transcripts are detected in the same region in control and narcoleptic sections (data not shown).