Figure 2.
Time-course effect (a) and maximal effect (b) of SSR240612 (0.3, 3, 10 and 30 mg kg−1, p.o.) on cold allodynia (paw-withdrawal response frequency) in rats fed with glucose (10% in drinking water) for 12 weeks. Effects of SSR240612 (10 and 30 mg kg−1, p.o.) are also shown in age-matched control rats. Data are means±s.e.mean of (n) rats in each group. Statistical comparison to vehicle (* in a), control (* in b) or pre-administration values (time 0) (+) is indicated by +P<0.05; ++**P<0.01; ***P<0.001.